Equilibrium

HoloRam Equilibrium

Equilibrium is a bioregulator aimed at enhancing the body's nutritional and energy balance. It might bolster the body's natural stress-related systems. Its believed method of action encompasses:**

• Sustaining the natural processes that adjust to various stress forms. This blend of adaptive components and energy modulators could uphold the well-being of the vegetative nervous system, central nervous system, and innate stress response systems. This promotes a harmonious adaptation to shifting physical and emotional environmental demands.
• Modulating the operations of the hypothalamus and pituitary axis.
• Augmenting the body's energy response to both external and internal stress triggers.
• Harmonizing the body's Yin and Yang pathways.

Ingredients

Composition:

• Group I. Adaptogens (Phytotherapeutic extracts): Green tea extract, Nebulised (Theasinensis, leaf, 20% total polyphenols) 94 mg, Aloe vera dry extract (Aloe vera, leaves pulp) 70 mg, Celandine powder (Chelidonium majus l., aboveground, 0.6% Total alkaloids)expressed as chelidonia) 42 mg, Lemon balm powder (Melissa officinalis l., leaf, 1% rosmarinic acid) 36 mg,Valerian powder (Valeriana officinalis l., 0.17%) 26 mg, Hypericum extract nebulized (Hypericum perforatum 0.3% hypericin) 26 mg, Thyme dust (Thymus vulgaris l., leaves and whole flowers, 1.2% essential oil) 21 mg, Eleutherococcus powder (Eleutherococcus senticosus, root) 18 mg, Fireweed (Epilobium parviflorum 1% total flavonoids (hiperosido) 16 mg, California poppy (Eschscholzia californica 2% flavonoids) 4 mg.
• Group II. Amino acids: L-serine 21 mg.
• Group III. Vitamins and minerals: Magnesium gluconate (5.86% magnesium) 26 mg, Silicon dioxide 0.4 mg.

Contents: 60 capsules (500 mg).

Instructions: Take 1 or 2 a day, preferably before breakfast and dinner, Or as advised by your physician.

Research Studies on Ingredients of Equilibrium

Group I. Adaptogens (Phytotherapeutic extracts)

• Green tea extract, Nebulised (Theasinensis, leaf, 20% total polyphenols)

  • Features: Enriched with a variety of polyphenols.
  • Benefits in stress regulation: Offers antioxidative capabilities and promotes cognitive functionality during stressful times.
  • References: Dietz, C., & Dekker, M. (2017). Effect of Green Tea Phytochemicals on Mood and Cognition. Current pharmaceutical design, 23(19), 2876-2905.
    
    

• Aloe vera dry extract (Aloe vera, leaves pulp)

  • Features: Abundant in polysaccharides and glycoproteins.
  • Benefits in stress regulation: Helps in modulating the body's response to stress.
  • References: Langmead, L., et al. (2004). Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Alimentary pharmacology & therapeutics, 19(5), 521-527.
    
    

• Celandine powder (Chelidonium majus l., aboveground, 0.6% Total alkaloids)

  • Features: Encompasses a variety of alkaloids.
  • Benefits in stress regulation: May offer properties that protect the nervous system.
  • References: Not directly associated with stress regulation.
    
    

• Lemon balm powder (Melissa officinalis l., leaf, 1% rosmarinic acid)

  • Features: Contains valuable essential oils and tannins.
  • Benefits in stress regulation: Aids in diminishing anxiety and inducing calmness.
  • References: Kennedy, D. O., et al. (2004). Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology, 29(10), 1871-1881.
    
    

• Valerian powder (Valeriana officinalis l., 0.17%)

  • Features: Enriched in valerenic acid.
  • Benefits in stress regulation: Acts as a calming agent, diminishing anxiety and fostering relaxation.
  • References: Bent, S., et al. (2006). Valerian for sleep: a systematic review and meta-analysis. The American journal of medicine, 119(12), 1005-1012.
    
    

• Hypericum extract nebulized (Hypericum perforatum 0.3% hypericin)

  • Features: Comprises the active constituent hypericin.
  • Benefits in stress regulation: Recognized for its mood-enhancing effects.
  • References: Linde, K., et al. (2008). St John's wort for major depression. Cochrane Database of Systematic Reviews, (4).
    
    

• Thyme dust (Thymus vulgaris l., leaves and whole flowers, 1.2% essential oil)

  • Features: Abundant in essential oils.
  • Benefits in stress regulation: Might have a calming influence on the nervous system.
  • References: Not directly linked to stress regulation.
    
    

• Eleutherococcus powder (Eleutherococcus senticosus, root)

  • Features: Contains eleutherosides.
  • Benefits in stress regulation: Recognized as an adaptogen that boosts the body's resilience to stress.
  • References: Panossian, A., & Wikman, G. (2009). Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Current clinical pharmacology, 4(3), 198-219.
    
    

• Fireweed (Epilobium parviflorum 1% total flavonoids)

  • Features: Contains an assortment of flavonoids.
  • Benefits in stress regulation: Potential antioxidative and neuroprotective attributes.
  • References: Not directly associated with stress regulation.
    
    

• California poppy (Eschscholzia californica 2% flavonoids)

  • Features: High presence of flavonoids.
  • Benefits in stress regulation: Assists in promoting relaxation.
  • References: Rolland, A., et al. (2001). Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytotherapy Research, 15(5), 377-381.

Group II. Amino acids

• L-serine
  • Features: It's a non-essential amino acid.
  • Benefits in stress regulation: Supports overall brain health and neurotransmitter synthesis.
  • References: Furuya, S., et al. (2000). The role of D-serine and its biosynthesis in mammalian brain. Current medicinal chemistry, 7(5), 529-537.

Group III. Vitamins and minerals

• Magnesium gluconate (5.86% magnesium)

  • Features: Contains the vital mineral magnesium.
  • Benefits in stress regulation: Supports nervous system functionality and offers relaxation effects.
  • References: Sartori, S. B., et al. (2012). Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment. Neuropharmacology, 62(1), 304-312.
    
    

• Silicon dioxide

  • Features: Naturally found in the earth's crust.
  • Benefits in stress regulation: No direct linkage to stress management.
  • References: Not directly related to stress regulation.