Sindromet

Holoram Sindromet:

• It's a dietary supplement that serves as a supportive agent in the holistic regulation of metabolic syndrome, encompassing conditions such as diabetes, obesity, hypertension, cholesterol imbalances, triglyceride irregularities, and insulin resistance.

• Benefits include:

  • Aiding in the stabilization of blood sugar levels by enhancing insulin sensitivity.
  • Regulation of cholesterol and triglyceride concentrations.
  • Boosting energy production.
  • Safeguarding the cardiovascular system.

• Unique Characteristics:

  • The combined effect of berberine, policosanol, astaxanthin, and resveratrol offers a comprehensive impact, distinguishing Holoram Sindromet as a unique dietary supplement.
  • This blend not only assists in metabolic recovery but also boasts antioxidant qualities.
  • It has properties that result in lowering blood sugar levels, reducing cholesterol, and decreasing fats, making it valuable for conditions like type II diabetes, obesity, dyslipidemia, and atherogenesis.

Composition per capsule

• Group I. Adaptogens for bioregulation of metabolic syndrome: synergy between berberine and policosanol: berberine dry extract (Berberis aristata DC, Bark, 97% berberine), 200 mg; policosanol, 5 mg.
• Group II. Antioxidants: Synergy between astaxanthin and resveratrol. Resveratrol (Polygonum cuspidatum root, > 98%), 50 mg; astaxanthin powder (Haematococcus pluvialis, algae, 5% astaxanthin), 20 mg.
• Group III. Immunoregulation and systemic metabolic effect: Vitamin D3 (cholecalciferol, 100,000 IU/g), 1.25 µg.
• Group IV. Components with effect on mitochondrial energy production: L-citrulline-DL-malate, 60 mg; magnesium malate (20% magnesium), 50 mg; coenzyme Q10, 10 m; adenosine 5’-monophosphate (AMP), 0.1 mg; nicotinamide adenine dinucleotide, disodium salt (NADH), 0.1 mg.
• Group V. Amino acids with hepatoprotective effect: L-methionine, 40 mg.
• Group VI. Probiotics. Synergistic effect on metabolic syndrome: mixture of probiotics: Bifidobacterium animalis spp lactis LMG 18314, Lactobacillus plantarum LMG 26367, Bifidobacterium longum LMG, Lactobacillus acidophilu

Research Studies on Ingredients of Sindromet

Group I. Adaptogens for bioregulation of metabolic syndrome: synergy between berberine and policosanol

• Berberine dry extract (Berberis aristata DC, Bark, 97% berberine), 200 mg:

  • Features:
    • Alkaloid compound derived from several different plants.
    • Demonstrates significant anti-diabetic properties.
  • Benefits:
    • May improve insulin sensitivity.
    • Can reduce blood sugar levels.
  • References:
    • Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis

• Policosanol, 5 mg:

  • Features:
    • A mixture of alcohols derived from the wax of sugar cane.
    • Demonstrates cholesterol-lowering properties.
  • Benefits:
    • Can reduce LDL (bad) cholesterol.
    • May increase HDL (good) cholesterol.
  • References:
    • Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent

Group II. Antioxidants: Synergy between astaxanthin and resveratrol

• Resveratrol (Polygonum cuspidatum root, > 98%), 50 mg:

  • Features:
    • Found in grapes, red wine, and certain berries.
    • Powerful antioxidant properties.
  • Benefits:
    • May protect against heart disease.
    • Can enhance antioxidant defenses.
  • References:
    • Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

• Astaxanthin powder (Haematococcus pluvialis, algae, 5% astaxanthin), 20 mg:

  • Features:
    • A carotenoid pigment found in certain algae and seafood.
    • Powerful antioxidant properties.
  • Benefits:
    • May reduce oxidative stress.
    • Can improve skin health and reduce signs of aging.
  • References:
    • Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet-induced apoptosis in keratinocytes

Group III. Immunoregulation and systemic metabolic effect

• Vitamin D3 (cholecalciferol, 100,000 IU/g), 1.25 µg:
  • Features:
    • A fat-soluble vitamin essential for calcium absorption.
    • Plays a vital role in bone health and immune function.
  • Benefits:
    • Supports bone and teeth health.
    • Enhances the pathogen-fighting effects of monocytes and macrophages.
  • References:
    • Vitamin D and the immune system

Group IV. Components with effect on mitochondrial energy production

• L-citrulline-DL-malate, 60 mg:

  • Features:
    • Combines the amino acid citrulline with malate, an organic salt.
    • Improves nitric oxide metabolism.
  • Benefits:
    • Supports increased blood flow.
    • Can improve athletic performance and muscle recovery.
  • References:
    • Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise

• Magnesium malate (20% magnesium), 50 mg:

  • Features:
    • Combination of magnesium and malic acid.
    • Important for many biochemical reactions in the body.
  • Benefits:
    • Can aid in energy production.
    • May alleviate symptoms of fibromyalgia and fatigue.
  • References:
    • The Effects of Magnesium Supplementation on Subjective Anxiety and Stress

• Coenzyme Q10, 10 mg:

  • Features:
    • Found naturally in the body and aids mitochondrial energy production.
  • Benefits:
    • Supports heart health.
    • May boost energy and speed recovery from exercise.
  • References:
    • The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure

• Adenosine 5’-monophosphate (AMP), 0.1 mg:

  • Features:
    • Involved in cellular energy transfer.
  • Benefits:
    • Supports cellular metabolism.
    • Can help in energy production.
  • References:
    • Effects of Adenosine 5'-Monophosphate on Induction of Thermogenesis and Reduction of Obesity in Zucker Rats

• Nicotinamide adenine dinucleotide, disodium salt (NADH), 0.1 mg:

  • Features:
    • Coenzyme that plays a crucial role in energy production.
  • Benefits:
    • May support brain function.
    • Potentially boosts energy levels.
  • References:
    • Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome

Group V. Amino acids with hepatoprotective effect

• L-methionine, 40 mg:
  • Features:
    • Essential amino acid.
    • Vital for many bodily functions.
  • Benefits:
    • Supports liver function.
    • Can act as an antioxidant.
  • References:
    • L-methionine supplementation and risk of colorectal adenomas

Group VI. Probiotics. Synergistic effect on metabolic syndrome

• Mixture of probiotics: Bifidobacterium animalis spp lactis LMG 18314, Lactobacillus plantarum LMG 26367, Bifidobacterium longum LMG, Lactobacillus acidophilus:
  • Features:
    • Beneficial bacteria strains.
    • Improve the balance of the gut microbiome.
  • Benefits:
    • Supports digestive health.
    • Can aid in metabolic regulation.
    • May reduce inflammation and support immune function.
  • References:
    • Probiotics and metabolic syndrome: a comprehensive review of their therapeutic potential